Description
Axion BioSystems’ Maestro Z platform uses noninvasive electrical impedance for real-time, continuous, label-free monitoring of your cells. Cell-based assays enable rapid evaluation of human biology in vitro, with substantial advantages in throughput and cost over tissue or animal models. However, many cell-based assays are endpoint assays, limited to a single snapshot in time. The Maestro Z platform’s real-time data reveals the kinetics of cell-cell interactions and cell-drug responses for better mechanistic understanding without the time- and cost-intensive process of repeating multiple endpoint assays. Over minutes or weeks, gain unprecedented access to your biology. Perfect for tracking immune cell-mediated killing, measuring cell proliferation and viability, studying the dynamics of cytotoxicity, and monitoring GCPR-mediated signaling, the Maestro Z platform delivers an easy-to-use, compact cellular analysis system suitable for any lab.
System features - Continuous cell monitoring - 96 simultaneous live recordings from your cells. Now you can track cell proliferation, morphology, and viability in real-time, even when you are out of the lab.
- See your cells - Sometimes you just want to look at your cells under a microscope. Maestro Z’s 96-well plates have a viewing window in each well which allows cell visualization.
- Precise environment - No need for an additional cell culture incubator, saving valuable lab space and money. Maestro Z’s smart environmental chamber finely controls temperature and CO2 while rejecting electrical noise and mechanical vibrations.
- “One button setup” - Temperature and CO2 levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.
- Powerful data analysis - AxIS Z simplifies the setup, execution and analysis of your experiments. Now you can focus on the science rather than the data analysis.
Applications - Immuno-oncology - Want to evaluate killing kinetics of immune cells such as natural killer (NK) cells or cytotoxic T lymphocytes (CTL) with physiologically relevant effector cell to target cell ratios? Concerned about the possible confounding effects of labeling your cells? Track immune cell-mediated killing label-free and in real-time with Maestro Z.
- Cell proliferation & viability - Endpoint cell assays limit your findings to a single snapshot in time. The Maestro Z platform, however, uses impedance-based cell analysis for real-time, continuous, label-free monitoring of your cells. Reveal the kinetics of cell-cell interactions and cell-drug responses for improved mechanistic insights of your cell model.
- Cell signaling - GPCR binding results in conformational changes and downstream responses that can be measured by impedance. These small changes often occur rapidly, but can last minutes to hours with significant physiological consequences. The Maestro Z impedance assay allows you to sensitively and continuously measure the dynamics of cell signaling over minutes to hours without disturbing the cell biology.